Fele Essay Samples - What Is It?

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The Effect Of Cd44 Expression On Drug Resistance And Cell...

Ijeoma Unachukwu PI: Dr. Kyle Murphy Fall 2014 The Effect of CD44 Expression on Drug-Resistance and Cell Migration in the Zebra Fish Xenotransplant Model Abstract Introduction Xenotransplanting is an effective tool to look at the profileration and metastisi of cancer cells. Traditionally, xenotransplant experiments have been done in mice, but for this experient we used zebra fish. Xenotransplantation in mice can be timlely and costly and often times inefficient. Zebrafish on the other hand have can reproduce quicly and have similar systems to that of humans. One of the main benefits of using zebrafish a cancer xenotransplant model is that they do not develop an adaptive immune system until 14 days after post fertilization. This makes it possible for human cancer cells to survive when they are injected into the zebrafish embryos. (Evaluating human cancer cell metastasis in zebrafish Yong Teng, Xiayang Xie, Steven Walker, David T White, Jeff S Mumm and John K Cowell).Recent papers have already proven the similarities between human and zebrafish liver tumors at a molecular level. Also, studies have created carcinogen induced neoplasms that resemble human timo rs in zebra fish and they have metastasized. In every situation, human cancer cells and tissue have survived and proliferated in zebra fish provinf that it is a comparative tumor model. Not only can xenotransplanted zebrafish can support the normal development of the host and proliferation of transplanted human melanomaShow MoreRelatedA Study On Type 2 Diabetes Essay857 Words   |  4 Pagessolution. The best solution according to Dr. Leahy lays in understanding the mechanisms of insulin resistance and beta-cell function (3). With previous research suggesting that Insulin resistance may be caused by adipose tissue inflammation, Dr. Kodama from Stanford University School of Medicine and colleagues, set out to test these hypotheses. They started their research by using an expression-based genome-wide association study (eGWAS). This approach entitles using data from previously publishedRead MoreColorectal Cancer : The Third Most Common Cancer901 Words   |  4 Pagesrates. Conventional chemotherapy efficiently targets tumor bulk, however, a small subpopulation of cells, known as cancer stem cells (CSCs), contribute to resistance to therapy, tumor regrowth and relapse. These CSCs have been shown to be responsible for the initiation and maintenance of tumors, as well as chemotherapeutic resistance and cancer recurrence. Accordingly, targeting this group of cells has become a major key to improve the treatment of CRC. Salinomycin is a polyether antibiotic usedRead MoreIs Cancer A Dangerous And Fatal Diseases?898 Words   |  4 Pagesproliferation of cells. Cancer cells’ survival, progression and metastasis are tightly associated with the cellular components. For example, when cells metastasizing, they use cell protrusion which provided by actin cytoskeleton to penetrate the extracellular matrix, they also secrete plasminogen activator to increase protease plasmin’s activity in order to penetrate the membrane. Then some of the tumor cells transfer to another tissue and form metastatic tumor. The specific functions of several cell structuresRead MoreCell Structures And Transporters Unit Assessment901 Words   |  4 PagesCell Structures and Transporters Unit Assessment Cancer is one of the most dangerous and fatal diseases, which is caused by uncontrolled growth and proliferation of cells. Cancer cells’ survival, progression and metastasis are tightly associated with the cellular components. For example, when cells metastasizing, they use cell protrusion which provided by the actin cytoskeleton to penetrate the extracellular matrix, they also secrete plasminogen activator to increase protease plasmin’s activity inRead MoreSymptoms And Treatment Of Gi Cancer Resistance Networks3430 Words   |  14 Pagesfailure. GI cancer resistance networks are in part due to interactions between parallel signaling and aberrantly expressed microRNAs (miRNAs) that collectively promote the development and survival of drug-resistant cancer stem cells (CSCs) with epithelial-to-mesenchymal transition (EMT) characteristics. The lack of understanding of resistance networks associated with this subpopulation of cells as well as reductionist single protein/pa thway targeted approaches has rendered â€Å"effective drug design† a difficult

Discusses Alternative Predictors of Job Performance

Question: Indicate which of the higher-rater predictors (in terms of validity) you, as the HR Manager, would elect NOT to use in a selection process you designed for your company. Explain WHY you would not use these predictors, even though they have highly-rated validity? Answer: As a HR Manager I would certainly not elect to use various predictors that are highly rated including work sample test, general mental ability test, structured employment interview and peer rating in my selection process designed for my company(Terence, 2002). In work sample test the applicant may give his best shot that may be a fluke which gives topmost position to be the job contender. However the same applicant may not prove his worth to the company later on. Also its the feeling of responsibility that is required to be searched in the applicant that will motivate him to continue improving his skills and output at work. Therefore the vital need is to check for the commitment and motivation towards work than work sample test(Abiodun, 2009). The general mental ability test mostly proves that the applicant is a good crammer and may not have equally good understanding of the reality, facts and concepts in actual sense. Therefore depending on the general mental ability test for selection purpose may not prove beneficial to the company in the later stage(Oribabor, 2009). The structured employment interview may get affected by charismatic outlook of the applicant who may not possess the required skills and commitment towards work. This way the interviewee may make mistake in selecting the wrong applicant for the job depending on the way of his talking and responding to the interview questions(Armstrong, 2006). Peer ratings can also not be trusted as the peer may give their personal thoughts affected by the impression of the applicant. Also they may try to help the applicant through good remarks as they want the applicant to end with a good job. This way the good human being thoughts may divert the decision making based on true facts. Thus the peer review will not be proof that the applicant will have the required skills and knowledge for the job that he has applied for(Rowold, 2008). Bibliography Abiodun, E. (2009). Human Resource Management, an overview. Lagos: Concept Publication. Armstrong, M. (2006). A handbook of Human Resource Management Practice (10th edition). London: Kogan Page. Oribabor, P. (2009). Human Resource Management: A Strategic Approval. Human Resource Management, 9(4): 21-24. Rowold, J. (2008). Multiple effect of Human Resource Development interventions. Journal of European Industrial Training, 32-44. Terence, J. (2002). International HRM: A Cross-Cultural Approach. London: Sage Publications.

The Young Offenders Act Essays - Criminal Law, Young Offender

The Young Offenders Act This essay was written to show the advantages and disadvantages of the Young Offenders Act over the previous Juvenile Delinquents Act. Also it should give a theoretical underezding of the current Canadian Juvenile-Justice system, the act and it's implications and the effects of the young offenders needs and mental health on the outcome of the trials. In the interest of society the young offenders act was brought forth on april second 1984. This act was created to ensure the rights and the needs of a young person. Alan W. Leshied says "On one hand the justice and legal objectives of the act are being effectively realized while on the other hand the needs and treatment aspects of it leave much to be desired." The research of the Young offenders act is still ongoing but Leshied says that it is becoming clear that the custody positions have been in dispute since the act came into effect. The old Juvenile delinquency act states in section 38 "The care and custody and discipline of a juvenile delinquent shall approximate as nearly as maybe that which should be given by his parents, and... as far as practability every juvenile delinquent shall be treated, not as a criminal, but as a misguided and misdirected child . . . needing aid, encouragement, help and assiezce."(Page 72) If a youth is close to the adult age of 18 years they could be transfered to the adult justice system. This means that they would be given the same sentences as an adult including and up to life in prison. Many people have tried to correct this problem that they see as a weakness. Yet, so far their attempts have failed. Another weakness they find, is that the courts are expensive and unsatisfactory methods of dealing with crime that is not very serious. Before the fabrication of legal aid most young offenders were not able to obtain legal services. "Subsection 11 (4) provides that, were a young person wishes to obtain counsel but is not able to do so, the youth-court judge shall refer the young person to the provincial legal-aid, or assiezce program. If no such program is available or the young person is unable to obtain counsel through an available program, the youth court judge may, and on the request of the young person shall direct the young person to be represented by counsel." To establish a relationship between the young offender and the lawyer, thew lawyer must be able to receive instructions from his/her client. Usually there is little difficulty either receiving or carrieing out the instructions of his/her client. Special problems can arise when the client is a young person. The problems faced by this, is the young person may not be able to communicate with counsel. While the lawyer and young person need not a specific statement for the client as to a preferred outcome it should take form of a general expression of the client's feelings or attitudes in the major issues of the precedings the young person must be able to make decisions that may hold significant repercussions. Mental health of the young offender can also be a problem. Currently this issue is not addressed in the Young Offenders Act, before the mental health act can be enacted, extremely dangerous behaviour must be displayed. Before the age of 16 they are sometimes placed in hospitals for a short time under the authority of the legal guardians.